SPADE Platform Documentation
Comprehensive guide to the Synthetic Biology and AI-driven Discovery Engine for Antimicrobial Peptides
Platform Introduction
SPADE (Synthetic Biology and AI-driven Discovery Engine for Antimicrobial Peptides) is a comprehensive platform designed to accelerate the discovery and development of novel antimicrobial peptides through the integration of synthetic biology principles and artificial intelligence technologies.
Synthetic Biology
Engineering biological systems with novel functions for useful purposes
Artificial Intelligence
Machine learning models trained on biological sequence data
Antimicrobial Peptides
Novel therapeutic agents to combat antibiotic resistance
Key Features
An explanation of the core functionalities of the SPADE platform:
AMP Sequence Generation
Generate new potential antimicrobial peptide sequences based on advanced AI models trained on extensive biological datasets.
Activity Prediction
Evaluate the antimicrobial activity of input sequences against specific pathogens with high predictive accuracy.
Toxicity Assessment
Predict the potential toxicity of peptide sequences to host cells, helping identify safe therapeutic candidates.
Physicochemical Analysis
Calculate key parameters such as molecular weight, isoelectric point, and hydrophobicity for peptide sequences.
Database Integration
Provide access to and comparison with existing AMP databases, allowing researchers to contextualize their findings within current scientific literature and known sequences.
Platform Workflow Overview
Operating Procedures
How to use the SPADE platform effectively:
Function Selection
Choose your desired function from the navigation, such as "Search" or "Statistics" or "Tools".
Parameter Input
Depending on the selected function, input necessary parameters like target bacterial species, sequence length constraints, and activity thresholds.
Execute Analysis
Submit the task and wait for the platform's AI model to process. Complex analyses may take several minutes to complete.
View & Download Results
(Coming soon) Once the analysis is complete, view the detailed report on the results page and download relevant data in multiple formats (CSV, FASTA, PDF).
Note: This is a general operational flow. Specific steps may vary by function. Please refer to the help documentation for each functional module for details.
User Guide / 使用指南
Database Retrieval / 数据库检索
Use the Search page to query curated AMP entries. Filter results by species, activity spectrum, sequence length, physicochemical properties and more.
在搜索页面查询经过整理的抗菌肽条目，可按物种、活性谱、序列长度、理化性质等条件进行筛选。
Statistics Tools / 统计工具
A dedicated Statistics Tools page for batch analyses (length distribution, amino-acid frequency, property histograms) is under active development and will support FASTA/CSV uploads and result visualisation soon.
用于批量分析（长度分布、氨基酸频率、理化性质直方图）的统计工具页面正在开发中，届时将支持 FASTA/CSV 上传与结果可视化。
Quick Notes / 快速笔记
On each peptide detail page you will find a Quick Notes panel. Users can jot experimental ideas or literature references and export them later.
在每个肽详情页右侧均有快速笔记面板。用户可记录实验思路或文献备注，并可导出。
Tools Page / 工具页
The Tools page links to sequence-format converters, α-helical wheel plotters, and 3-D structure prediction services maintained by third parties.
工具页汇聚了序列格式转换、α螺旋轮图绘制以及三维结构预测等第三方工具链接。
Data are aggregated from public AMP databases and PubMed literature. While we strive for accuracy, records and underlying code components (including third-party libraries) may change without notice and could contain errors or omissions. The SPADE platform accepts no liability for any loss or damage arising from data inaccuracies, code issues, or future modifications.If you access, call, or use this website in any way, you shall be deemed to agree to and be aware of the relevant risks, even if you have not read the entire disclaimer section.
本平台数据来源于公开抗菌肽数据库及PubMed文献。尽管我们努力确保数据与代码准确可靠，但记录及底层代码组件（含第三方库）可能随时调整并可能存在错误或遗漏。因数据、代码问题或未来变动所导致的一切损失，SPADE概不承担任何责任。如果您访问、调用或使用本网站的任何方式，您应视为已同意并了解相关风险，即使您未阅读完整的免责声明部分。
Resources
Comprehensive materials to help you utilize the SPADE platform effectively:
User Manual
A complete guide to all features and functions of the SPADE platform, including detailed instructions and best practices.
DownloadAPI Reference
(Coming soon) Documentation for the SPADE API, including endpoints, request/response formats, authentication, and usage examples.
View Online Download PDF (coming soon)Tutorials
(Coming soon) Step-by-step guides and video tutorials to help you get started with the SPADE platform and its various features.
Browse TutorialsDisclaimer / 免责声明
Please read our disclaimer carefully before using this website. The following documents are available for viewing and downloading.
在使用本网站前，请仔细阅读我们的免责声明。以下文件可供查阅和下载。
Frequently Asked Questions
Answers to common questions about the SPADE platform:
Contact Us(Not filled yet)
Have questions or need support? Reach out to our team:
General Inquiries
For general questions about the SPADE platform or licensing information.
- Email: info@spade-platform.com
- Phone: +1 (555) 123-4567
Technical Support
For assistance with platform functionality, API integration, or troubleshooting.
- Email: support@spade-platform.com
- Hours: Monday-Friday, 9AM-5PM EST